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Peptides - Your Anti-aging Star Ingredient in Your Skincare Routine

Meet the rising star ingredient of the skincare industry that promises the youthfulness and radiance that everyone is striving for - Peptides. We’ve been flooded with buzz ingredients like Vitamin C, Retinol and Hyaluronic Acid in the past as the gold standard for anti-aging. Well, this time, the limelight belongs to the Peptides which has been outshone by its counter buzz ingredients for far too long. It's time to learn include peptides your skincare routine for the ultimate anti-aging skincare.


What are Peptides?

Peptides are essentially made up of short chains of building blocks known as amino acids that are held together by a peptide bond. They are essential fragmented protein molecules needed to maintain the structural and functional components of your skin such as elastin fibers and collagen, that helps keep your skin firm and youthful in appearance.


How does Peptide work?

Proteins such as collagen are large molecular weight molecules that are only able to sit on the surface of the skin. However, with peptides, the molecular weight and size allow them to penetrate the outer layer of the skin, thus sinking in more deeply into the layers of the skin. Imagine peptides as little messengers that trigger skin cells to perform certain functions for a particular benefit such as boosting collagen and elastin production for firmer skin and smoothing out wrinkles.


All Peptides are not created equal:

There are five different types of peptides related to skincare, each having a different function to help protect and restore the skin’s natural elasticity and firmness.

1. Signaling Peptides: Palmitoyl Pentapeptides

These peptides function to stimulate collagen, elastin, hyaluronic acid and epidermal growth factor (EGF) synthesis to reduce the formation of wrinkles and fine lines.


2. Signaling Peptides: Palmitoyl Pentapeptides Enzyme-inhibitor Peptides: Trifluoroacetyl Tripeptide-2, TrylagenSignaling Peptides: Palmitoyl Pentapeptides

These peptides function to act directly on enzymes such as Tyrosinase which is responsible for initiating the production of skin pigmentation in the skin. The result, a reduction in melanin production by the skin and a general lightening of the skin tone.


3. Carrier Peptides: Copper Peptides

These peptides work by transporting trace elements such as Copper and Manganese to facilitate wound healing. This is also the most researched peptide.


4. Antimicrobial Peptides: Defensins, Cathelicidins

This group of peptides can be produced by the body itself. They have broad antibacterial function and are part of the primary mechanism used by the skin in immune defense.


5. Neurotransmitter-inhibiting Peptides: Argireline

This group of peptides focuses on blocking the signal transmission between nerves and muscle to prevent muscle contraction of expression lines. This is commonly found in Botox injections.


Benefits of Peptides for the Skin

1. Stimulate collagen production in the skin

Collagen is a protein that is naturally produced by our bodies to maintain healthy joints and skin elasticity. Three quarters of this compound is found in the skin! However, as we age, the ability of the body to produce more collagen becomes much slower than the rate of the breakdown of collagen production. This is why our skin becomes thinner, drier and less elastic as we age. When peptide is applied to the skin, the short fragments of peptides are able to penetrate deeper into the skin to send signals to the body to increase collagen production that results in healthier, plumper looking skin.


2. Strengthen skin barrier

A strong and healthy skin barrier ensures that the moisture stays within the skin while keeping the bad stuff such as bacteria and pollutants out. When the skin barrier is compromised, skin issues such as acne, eczema and rosacea can occur, leading to flaky, weak and cracked skin, plus irritation Unlike larger molecules that sit on the surface of the skin, peptides are able to penetrate deeper into the layers of the skin, creating a firmer matrix and strengthening the skin barrier.


3. Has anti-inflammatory properties

There are certain peptides that contain amino acids Alanine and Tyrosine with high antioxidant properties that can help soothe and calm the skin, leading to less inflammation.


4. Helps reduce formation of wrinkles

Research has shown that when collagen-like peptide peptide is applied on the skin for over 4 weeks, the results showed significant  reduction in the total surface wrinkles, as well as, the depth and length of the wrinkles. Some peptides with neurotransmitter-inhibiting abilities are able to relax the muscle on underlying facial muscles to prevent the formation of wrinkles, making this ingredient a potential key player in anti-aging skincare routines.


5. Repair damaged skin

Several research studies have shown that synthetic peptides when applied topically have improved clinical outcomes in aged skin and wound-healing processes. The results have shown a reduction in skin roughness, improved elasticity and increased suppleness.


How to use Peptides

While peptides can be found as an ingredient in many types of skincare products from cleansers to serums to moisturizers, it is important to understand that the frequency and effectiveness depends on the type of products you choose that best suits your skin type. Peptides found in cleansers will not benefit your skin as compared to serums and moisturizers. This is because the length of time that the cleanser stays on your face is so short that there is insufficient time for the peptide to penetrate the skin and do its job before the cleanser is washed off from your skin. Therefore, using peptides in a form of serum or moisturizer would be much more effective.

Peptide is a great ingredient that works well with antioxidants (i.e., Vitamin C, Niacinamide, retinol) and hydrating ingredients such as Hyaluronic Acid. Depending on how sensitive your skin is, and the concentration of the ingredients that you are using, it is best to use the combination of products in separate routines to start and slowly pair them together in the same routine.

However, there are a few cautions. Firstly, Copper peptides should be used in a different routine from Vitamin C because copper, when mixed with Vitamin C can oxidize the Ascorbic Acid in Vitamin C, making it ineffective.

Secondly, avoid using peptides in the same routine as Alpha Hydroxy Acids (AHAs) and Beta Hydroxy Acids (BHAs) as acids have the ability to break down proteins and peptides being the precursors to protein can be rendered ineffective in the presence of acids.

Lastly, avoid using Copper peptides (specifically) and retinol together in a routine as Copper peptides increases blood flow to the skin which exacerbates the skin sensitivity that is often a side effect from the use of retinol.


Our Recommendations

Keep scrolling to find out some of our favourite and affordable peptide-containing k-beauty products.


If clean beauty is up your alley and you are looking for a well-rounded peptide serum, this Mary & May 6 Peptide Complex Serum would be a great option. This serum contains 6 types of hexapeptide and palmitoyl peptides to give an intense boost in collagen production for firmer looking skin. The clear, fragrance-free lightweight serum absorbs quickly into the skin without leaving any sticky residue behind.


Looking for an eye cream with peptide in its formulation? Try the Youth Lasting Real Eye Cream from AHC. This creamy texture of the eye cream when applied to the skin helps fill in the fine wrinkles around the eyes, giving the skin a boost of moisture.



Another great option for those interested in vegan based formulation, the Vegreen Fragrance-Free Nature Mucin Serum is a great option. This serum contains 63% of mucin from Wild Yam Extract and 5 types of peptides to help restore the skin elasticity without fragrance or ingredients that triggers sensitive skin irritation.



How about a combination of peptide and Vitamin C where you can get the ultimate boost in skin vitality? Look no further than SCINIC Vita C Dark Spot Concentrate Ampoule. This ampoule comes in a click and release ampoule bottle that allows you to mix the formulation when you are ready to use to reduce the chances of oxidation. Each bottle can last up to 1 month’s use after opening.


The Takeaway

Is our star ingredient worth the hype?  While there is much convincing evidence that this ingredient can do wonders for the skin, including my own personal experiences, choosing the right peptide for what you are looking to treat is key to maximize the benefits of this ingredient.



Pfalzgraff, A., Brandenburg, K., Weindl, G. Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds. Front Pharmacol 2018; 9: 281.  doi:10.3389/fphar.2018.00281.


Gorouhi, F., Maibach, HI. Role of Topical Peptides in Preventing or Treating Aged Skin. International Journal of Cosmetic Science 2009; 31: 327-345. doi:10.1111/j.1468-2494.2009.00490.x.


Baua, E., Oberto, G., Berghi, A., Farra Dal, C., Dombage, N.Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. Int J Tissue React. 2004;26(3-4):105-11.Retrieved from


Ganceviciene, R., Liakou, AI, Theodoridis, A., Makrantonaki, E., Zouboulis, C. Skin Anti-aging Strategies. Dermatoendocrinol. 2012 Jul 1; 4(3): 308–319.  doi:10.4161/derm.22804.


Ferreira, I. Identification of Antioxidant Peptides in Enzymatic Hydrolysates of Carp (Cyprinus Carpio) Skin Gelatin. Molecules.  2019 Jan; 24(1): 97. Published online 2018 Dec 28. doi:10.3390/molecules24010097.


Linus Pauling Institute. Peptides and Skin Health. Retrieved from


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